Annual report pursuant to Section 13 and 15(d)

Fair Value Measurements - Contingently Issuable Warrants with option pricing model (Detail)

v3.19.1
Fair Value Measurements - Contingently Issuable Warrants with option pricing model (Detail)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected dividend yield   0.00%
Helocyte [Member] | Measurement Input, Risk Free Interest Rate [Member] | Minimum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Risk-free interest rate   2.04%
Helocyte [Member] | Measurement Input, Risk Free Interest Rate [Member] | Maximum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Risk-free interest rate   2.08%
Helocyte [Member] | Measurement Input, Expected Dividend Rate [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected dividend yield   0.00%
Helocyte [Member] | Measurement Input, Expected Term [Member] | Minimum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected term in years   3 years 6 months
Helocyte [Member] | Measurement Input, Expected Term [Member] | Maximum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected term in years   3 years 11 months 1 day
Helocyte [Member] | Measurement Input, Price Volatility [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected volatility   70.00%
Caelum [Member] | Contingently Issuable Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member] | Minimum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Risk-free interest rate 2.905% 2.154%
Caelum [Member] | Contingently Issuable Warrants [Member] | Measurement Input, Risk Free Interest Rate [Member] | Maximum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Risk-free interest rate 2.909% 2.168%
Caelum [Member] | Contingently Issuable Warrants [Member] | Measurement Input, Expected Dividend Rate [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected dividend yield 8211.00% 8211.00%
Caelum [Member] | Contingently Issuable Warrants [Member] | Measurement Input, Expected Term [Member] | Minimum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected term in years 3 years 10 months 2 days 4 years 6 months 29 days
Caelum [Member] | Contingently Issuable Warrants [Member] | Measurement Input, Expected Term [Member] | Maximum [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected term in years 3 years 11 months 16 days 4 years 8 months 16 days
Caelum [Member] | Contingently Issuable Warrants [Member] | Measurement Input, Price Volatility [Member]    
Fair Value Measurement Inputs and Valuation Techniques [Line Items]    
Expected volatility 70.00% 70.00%