Annual report pursuant to Section 13 and 15(d)

Debt and Interest - Schedule of Interest Expenses for Debt Arrangements (Detail)

v3.6.0.2
Debt and Interest - Schedule of Interest Expenses for Debt Arrangements (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Debt [Line Items]      
Financing fee $ 1,032 $ 0 $ 0
Total Interest Expense and Financing Fee 3,690 1,484 1,338
LOC Fees [Member]      
Debt [Line Items]      
Interest 11 0 0
Interest and Debt Expense 11 0 0
IDB Note [Member]      
Debt [Line Items]      
Interest 328 314 292
Amortization of fees 1 5 4
Interest and Debt Expense 329 319 296
NSC Debt [Member]      
Debt [Line Items]      
Interest 599 690 0
Amortization of fees 1,270 309 0
Interest and Debt Expense 1,869 999 0
Ovamed [Member]      
Debt [Line Items]      
Interest 0 166 154
Interest and Debt Expense 0 166 154
Opus Credit Facility [Member]      
Debt [Line Items]      
Interest 192 0 0
Amortization of fees 195 0 0
Interest and Debt Expense 387 0 0
Helocyte Convertible Note [Member]      
Debt [Line Items]      
Interest 61 0 0
Financing fee 962 0 0
Interest and Debt Expense 1,023 0 0
Avenue Convertible Note [Member]      
Debt [Line Items]      
Financing fee 70 0 0
Interest and Debt Expense 70 0 0
Hercules Debt [Member]      
Debt [Line Items]      
Interest [1] 0 0 845
Amortization of fees 0 0 43
Interest and Debt Expense 0 0 888
D&O Insurance [Member]      
Debt [Line Items]      
Interest 1 0 0
Interest and Debt Expense $ 1 $ 0 $ 0
[1] Interest expense related to the Company’s loan with Hercules was $0.8 million, including $0.4 million related to accretion of the debt discount for the year ended December 31, 2014.