Licenses Acquired - Additional Information (Detail) - USD ($)
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1 Months Ended |
3 Months Ended |
12 Months Ended |
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May 11, 2015 |
Oct. 31, 2016 |
Sep. 30, 2016 |
May 31, 2016 |
Feb. 23, 2016 |
Dec. 31, 2015 |
Oct. 31, 2015 |
Sep. 30, 2015 |
Jul. 16, 2015 |
Jun. 17, 2015 |
Apr. 28, 2015 |
Mar. 31, 2015 |
Feb. 28, 2015 |
Dec. 31, 2016 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
Dec. 01, 2016 |
Jul. 31, 2016 |
Jun. 01, 2016 |
Feb. 17, 2015 |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payments to Acquire Intangible Assets |
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$ 350,000
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$ 1,250,000
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$ 0
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Research And Development In Process |
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5,532,000
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11,408,000
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0
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Stock Issued During Period, Shares, Issued for Services |
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10,000
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Stock Issued During Period, Value, Issued for Services |
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2,000
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1,000
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4,000
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Research And Development Expense |
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(35,134,000)
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(29,810,000)
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Payments to Acquire in Process Research and Development |
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200,000
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Share Price |
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$ 2.39
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$ 2.82
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Stock Issued During Period, Value, Other |
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3,502,000
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Proceeds From Issuance Of Common Stock |
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0
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0
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3,502,000
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Share-based Compensation |
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$ 12,128,000
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$ 14,291,000
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5,546,000
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Common Stock Shares Authorized |
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100,000,000
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100,000,000
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100,000,000
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100,000,000
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Common Stock [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Stock Issued During Period, Shares, Issued for Services |
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500,000
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Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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$ 22,000,000
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$ 10,700,000
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Sale Millstone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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7,000,000
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26,200,000
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NeuPharma [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Research And Development In Process |
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$ 1,000,000
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$ 1,000,000
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NeuPharma [Member] | Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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40,000,000
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NeuPharma [Member] | Sale Millstone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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40,000,000
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NeuPharma [Member] | Regulatory Approvals To Commercialize Products [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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$ 22,500,000
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City Of Hope [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Marketability Percentage Of Invested Capital |
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44.80%
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Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
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30.00%
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Share Price |
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$ 0.147
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Stock Issued During Period, Value, Other |
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$ 100,000
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City Of Hope [Member] | Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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$ 1,500,000
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City Of Hope [Member] | Sale Millstone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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13,000,000
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National Institutes of Health [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payment of Upfront Milestone Fees |
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700,000
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New Zealand Pharmaceuticals Ltd [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Reimbursement Revenue |
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600,000
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Dana-Farber [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Shares Issued, Price Per Share |
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$ 0.065
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Stock Issued During Period, Shares, Issued for Services |
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500,000
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136,830
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Stock Issued During Period, Value, Issued for Services |
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$ 32,500
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$ 600,000
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Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
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5.00%
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5.00%
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Proceeds From Issuance Of Common Stock |
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$ 10,000,000
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Dana-Farber [Member] | First Commercial Sale Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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21,500,000
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Dana-Farber [Member] | Additional Sales Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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60,000,000
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Mustang Bio, Inc [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Royalty Guarantees, Commitments, Amount |
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$ 1,000,000
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Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
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10.00%
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Minimum Annual Royalty Payable |
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$ 1,000,000
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Mustang Bio, Inc [Member] | Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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14,500,000
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Mustang Bio, Inc [Member] | Financial Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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2,000,000
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Escala Therapeutics, Inc [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payment of Upfront Fees |
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$ 1,300,000
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Reimbursement Revenue |
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$ 1,300,000
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Gene Medicine, Inc [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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19,300,000
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Royalty Guarantees, Commitments, Amount |
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|
$ 100,000
|
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$ 300,000
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Effcon Laboratories, Inc [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payment of Upfront Fees |
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|
$ 200,000
|
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Revenue Recognition Milestone Method Payments Due |
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|
5,300,000
|
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Royalty Guarantees, Commitments, Amount |
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|
$ 1,600,000
|
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Teva Pharmaceutical Industries Ltd [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payments for Fees |
|
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|
$ 500,000
|
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Teva Pharmaceutical Industries Ltd [Member] | Regulatory Approvals To Commercialize Products [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method Payments Due |
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|
|
206,500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Teva Pharmaceutical Industries Ltd [Member] | Clinical Development and Regulatory Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
$ 220,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2,000,000
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 87,500,000
|
|
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
50.00%
|
50.00%
|
|
|
|
|
|
|
Payment Of Upfront Licensing Fee |
|
|
|
|
$ 2,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Royalty Revenue |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 1,500,000
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Sale Millstone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Milestone Method Revenue Additional Payments Eligible To Receive |
|
|
|
|
89,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Regulatory Approvals To Commercialize Products [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
59,500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Successful Achievement Of One Preclinical Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
300,000
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Completion Of Three Clinical Development Milestones For Two Licensed Products [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
25,500,000
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Five Regulatory Approvals And First Commercial Sales [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
61,700,000
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Three Sales Milestones Based On Aggregate Net Sales [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
89,000,000
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Clinical Development and Regulatory Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
$ 89,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | TG Therapeutics, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payment Of Upfront Licensing Fee |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1,000,000
|
|
|
|
|
|
|
Collaborative Agreements with TGTX [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
500,000
|
|
|
|
|
|
|
600,000
|
600,000
|
|
|
|
|
|
Collaborative Agreements with TGTX [Member] | NeuPharma [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
42,000
|
|
|
|
|
|
|
Agreement With City Of Hope [Member] | Mustang Bio, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payment Of Upfront Licensing Fee |
|
|
|
|
|
|
|
|
|
|
|
|
2,000,000
|
|
|
|
|
|
|
|
|
|
Triplex [Member] | City Of Hope [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum Annual Royalty Payable |
|
|
|
|
|
|
|
|
|
|
|
750,000
|
|
|
|
|
|
|
|
|
|
|
Pentameter [Member] | City Of Hope [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum Annual Royalty Payable |
|
|
|
|
|
|
|
|
|
|
|
750,000
|
|
|
|
|
|
|
|
|
|
|
Pentameter [Member] | City Of Hope [Member] | Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
5,500,000
|
|
|
|
|
|
|
|
|
|
|
Pentameter [Member] | City Of Hope [Member] | Sale Millstone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
26,000,000
|
|
|
|
|
|
|
|
|
|
|
Coronado SO Co, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 0
|
$ 1,607,000
|
0
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 900,000
|
|
|
|
|
|
|
|
|
Stock Issued During Period, Shares, Other |
|
|
|
|
|
|
|
|
|
|
|
|
|
150,000
|
|
|
|
|
|
|
|
|
Research And Development Expense |
|
|
|
|
|
|
|
$ 500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
|
|
|
|
13.00%
|
|
|
|
|
|
|
|
13.00%
|
13.00%
|
13.00%
|
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 3,160,000
|
$ 3,159,000
|
0
|
|
|
|
|
Stock Issued During Period, Value, Purchase of Assets |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 22,000,000
|
|
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
[1] |
|
|
|
|
|
62.30%
|
|
|
|
|
|
|
|
62.90%
|
62.90%
|
62.30%
|
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | First Commercial Sale Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
21,500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Additional Sales Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
60,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Clinical Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
7,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Commercial Sales In Specified Territories [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
$ 14,500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Dana-Farber [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock Issued During Period, Value, Purchase of Assets |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 5,500,000
|
|
|
|
|
|
|
Helocyte [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
|
|
|
200,000
|
|
|
|
$ 53,000
|
$ 200,000
|
$ 0
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
20.50%
|
20.50%
|
|
|
|
|
|
|
Helocyte [Member] | Triplex [Member] | Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
9,000,000
|
|
|
|
|
|
|
|
|
|
|
Helocyte [Member] | Triplex [Member] | Sale Millstone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
|
|
|
|
|
|
|
|
|
26,000,000
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments to Acquire Intangible Assets |
|
|
|
|
|
|
|
|
|
|
|
$ 45,000
|
$ 150,000
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | City Of Hope [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketability Percentage Of Invested Capital |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
44.50%
|
|
|
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
30.00%
|
|
|
|
|
|
|
Share Price |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 0.097
|
$ 0.097
|
|
|
|
|
|
|
Stock Issued During Period, Value, Other |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 48,500
|
|
|
|
|
|
|
Licensing Agreements [Member] | City Of Hope [Member] | Common Class A [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncash or Part Noncash Acquisition, Noncash Financial or Equity Instrument Consideration, Shares Issued |
|
|
|
|
500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Dana-Farber [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 1,000,000
|
|
|
|
|
|
Licensing Agreements [Member] | Mustang Bio, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock Issued During Period, Shares, Issued for Services |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
293,588
|
|
|
|
|
|
|
|
Stock Issued During Period, Value, Issued for Services |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 1,700,000
|
|
|
|
|
|
|
|
Share Price |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 5.73
|
$ 5.73
|
|
|
|
|
|
|
Proceeds from Third Party Investors |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 10,000,000
|
|
|
|
|
|
|
|
Common Stock Shares Authorized |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1,000,000
|
1,000,000
|
|
|
|
|
|
|
Licensing Agreements [Member] | Cellvation Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketability Percentage Of Invested Capital |
|
|
40.20%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock Issued During Period, Shares, Issued for Services |
|
|
500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
|
|
30.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Share Price |
|
|
$ 0.024
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Stock Issued During Period, Value, Other |
|
|
$ 12,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payment of Upfront Fees |
|
|
$ 300,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
5.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Cellvation Inc [Member] | Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
$ 6,200,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Cellvation Inc [Member] | Sale Millstone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
6,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Cellvation Inc [Member] | Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional Minimum Annual Royalty Payable |
|
|
50,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Cellvation Inc [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Additional Minimum Annual Royalty Payable |
|
|
200,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Cellvation Inc [Member] | Research and Development - Licenses Acquired [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Share-based Compensation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 12,000
|
|
|
|
|
|
|
Licensing Agreements [Member] | Coronado SO [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketability Percentage Of Invested Capital |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
44.80%
|
|
|
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
30.00%
|
|
|
|
|
|
|
Share Price |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 1.19
|
$ 1.19
|
|
|
|
|
|
|
Licensing Agreements [Member] | IV Tramadol [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments to Acquire Intangible Assets |
|
|
|
|
|
|
|
|
|
|
$ 1,000,000
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 2,000,000
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Helocyte [Member] | Common Class A [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncash or Part Noncash Acquisition, Noncash Financial or Equity Instrument Consideration, Shares Issued |
|
|
|
|
8,333
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Avenue Therapeutics, Inc. [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Shares Issued, Price Per Share |
|
|
|
|
|
|
$ 0.146
|
|
|
|
|
|
|
|
|
|
$ 0.146
|
|
|
|
|
|
Research And Development Expense |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 14,000
|
$ 29,000
|
|
|
|
|
|
Debt Instrument, Fee Amount |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 3,000,000
|
Secondary License [Member] | Cellvation Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payment of Upfront Fees |
|
|
50,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method Payments Due |
|
|
300,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Second TBI License [Member] | Cellvation Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum Annual Royalty Payable |
|
|
$ 100,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|