The following table shows the details of interest expense for all debt arrangements during the periods presented. Interest expense includes contractual interest and amortization of the debt discount and amortization of fees represents fees associated with loan transaction costs, amortized over the life of the loan: | | For the Years Ended December 31, | | ($ in thousands) | | 2016 | | 2015 | | 2014 | | IDB Note | | | | | | | | | | | Interest | | $ | 328 | | $ | 314 | | $ | 292 | | Amortization of fees | | | 1 | | | 5 | | | 4 | | Total IDB Note | | | 329 | | | 319 | | | 296 | | | | | | | | | | | | | NSC Debt | | | | | | | | | | | Interest | | | 599 | | | 690 | | | - | | Amortization of fees | | | 1,270 | | | 309 | | | - | | Total NSC Debt | | | 1,869 | | | 999 | | | - | | | | | | | | | | | | | Opus Credit Facility | | | | | | | | | | | Interest | | | 192 | | | - | | | - | | Amortization of fees | | | 195 | | | - | | | - | | Total Opus Note | | | 387 | | | - | | | - | | | | | | | | | | | | | Ovamed | | | | | | | | | | | Interest | | | - | | | 166 | | | 154 | | Total Ovamed | | | - | | | 166 | | | 154 | | | | | | | | | | | | | LOC Fees | | | | | | | | | | | Interest | | | 11 | | | - | | | - | | Total LOC | | | 11 | | | - | | | - | | | | | | | | | | | | | Helocyte Convertible Note | | | | | | | | | | | Interest | | | 61 | | | - | | | - | | Financing fee | | | 962 | | | - | | | - | | Total Helocyte Convertible Note | | | 1,023 | | | - | | | - | | | | | | | | | | | | | Avenue Convertible Note | | | | | | | | | | | Financing fee | | | 70 | | | - | | | - | | Total Avenue Convertible Note | | | 70 | | | - | | | - | | | | | | | | | | | | | Hercules Debt | | | | | | | | | | | Interest (1)
| | | - | | | - | | | 845 | | Amortization of fees | | | - | | | - | | | 43 | | Total Hercules Debt | | | - | | | - | | | 888 | | | | | | | | | | | | | D&O Insurance | | | | | | | | | | | Interest | | | 1 | | | - | | | - | | Total D&O Insurance | | | 1 | | | - | | | - | | Total Interest Expense and Financing Fee | | $ | 3,690 | | $ | 1,484 | | $ | 1,338 | | | (1)
| Interest expense related to the Company’s loan with Hercules was $0.8 million, including $0.4 million related to accretion of the debt discount for the year ended December 31, 2014.
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