Annual report pursuant to Section 13 and 15(d)

Fair Value Measurements (Common Stock Warrant Liabilities) (Details)

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Fair Value Measurements (Common Stock Warrant Liabilities) (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2022
Dec. 16, 2022
Oct. 11, 2022
Dec. 31, 2022
Dec. 31, 2021
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Common Stock Warrant liabilities at beginning of period       $ 0  
Change in fair value of Warrant liabilities       (1,129) $ 447
Satisfaction of partner company contingent payment         (4,628)
Common Stock Warrant liabilities at end of period $ 13,869     13,869 0
Contingent Payment Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Change in fair value of Warrant liabilities         447
Checkpoint Common Stock Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Common Stock Warrant liabilities at end of period 11,170     11,170  
Checkpoint Common Stock Warrants | Common Stock Warrant          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants       7,640  
Change in fair value of Warrant liabilities 3,300 $ (1,200)   3,252  
Checkpoint Common Stock Warrants | Placement Agent Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants       278  
Avenue Therapeutics, Inc [Member]          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants     $ 8,278    
Common Stock Warrant liabilities at end of period     2,609    
Avenue Therapeutics, Inc [Member] | Common Stock Warrant          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants       8,278  
Change in fair value of Warrant liabilities     $ (5,669) (5,669)  
Urica | Contingent Payment Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Common Stock Warrant liabilities at beginning of period       0  
Common Stock Warrant liabilities at end of period $ 100     100 0
Urica | Placement Agent Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants       $ 90  
Journey | Contingent Payment Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants         3,819
Journey | Placement Agent Warrants          
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]          
Issuance of Warrants         $ 362