Annual report pursuant to Section 13 and 15(d)

Collaboration and Stock Purchase Agreements and Asset Acquisitions (Narrative) (Details)

v3.23.1
Collaboration and Stock Purchase Agreements and Asset Acquisitions (Narrative) (Details)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 12 Months Ended
Oct. 11, 2022
USD ($)
Oct. 06, 2021
Oct. 05, 2021
USD ($)
Feb. 24, 2021
USD ($)
Milestone
Nov. 12, 2018
Sep. 30, 2021
USD ($)
Feb. 28, 2019
USD ($)
$ / shares
shares
Dec. 31, 2022
USD ($)
Dec. 31, 2021
USD ($)
Collaboration revenue               $ 1,882 $ 5,389
Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                  
Upfront fees payment       $ 8,000          
Payments of milestones       $ 12,000          
Percentage of ownership over any FDA priority review voucher       100.00%          
Number of development milestones | Milestone       2          
Collaboration revenue               $ 1,900 $ 5,400
Avenue Therapeutics, Inc [Member] | InvaGen [Member]                  
Percentage of shares repurchased 100.00%                
Purchase price of shares repurchased $ 3,000                
Percentage of contingent fee payable 7.50%                
Contingent fee payable from proceeds of future financing $ 4,000                
Caelum | AstraZeneca [Member]                  
Deconsolidation of consolidated partner company, percentage deconsolidated   100.00% 100.00%            
Percentage of proceeds from option exercise     42.40%     42.40%      
Option exercise price     $ 150,000     $ 150,000      
Proceeds from option exercise     $ 56,900     $ 56,900      
Percentage of escrow holdback     10.00%            
Revenue from collaboration agreement     $ 148,600            
Maximum | Caelum | AstraZeneca [Member]                  
Revenue from collaboration agreement     $ 350,000            
SPMA [Member] | Avenue Therapeutics, Inc [Member] | InvaGen [Member]                  
Sale of stock, ownership percentage after the transaction         33.30%        
FDA approval of the NDA [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                  
Payments of milestones       $ 9,000          
Strategic Transaction, First Stage [Member] | SPMA [Member] | Avenue Therapeutics, Inc [Member] | InvaGen [Member]                  
Sale of stock, number of shares issued | shares             5.8    
Stock offering, price per share | $ / shares             $ 6.00    
Sale of Stock, Consideration Received on Transaction             $ 35,000    
Sale of stock, ownership percentage after the transaction             33.30%    
Completion of Clinical Development Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                  
Payments of milestones       $ 3,000