Annual report [Section 13 and 15(d), not S-K Item 405]

Segment Information (Schedule of Segment Information) (Details)

v3.25.1
Segment Information (Schedule of Segment Information) (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Revenue    
Product revenue, net $ 55,134 $ 59,662
Collaboration revenue 1,500 5,229
Other revenue 1,000 19,519
Net revenue 57,675 84,513
Operating expenses    
Cost of goods - product revenue 20,879 22,893
Amortization of acquired intangible assets 3,424 3,767
Research and development 56,629 101,747
Research and development - licenses acquired 252 4,324
Selling, general and administrative 87,731 90,981
Loss recovery (4,553)  
Asset impairment 3,692 3,143
Total operating expenses 168,054 226,855
Loss from operations (110,379) (142,342)
Other income (expense)    
Interest Income 2,683 3,003
Interest expense and financing fee (13,527) (15,315)
Gain (loss) on common stock warrant liabilities (638) 4,424
Other income (expense) 1,318 (3,403)
Total other income (expense) (10,164) (11,291)
Loss before income tax expense (120,543) (153,633)
Income tax expense benefit 312 521
Net loss (120,855) (154,154)
Net loss attributable to non-controlling interests 74,858 93,517
Net Income (Loss) (45,997) (60,637)
Research and development (56,629) (101,747)
Segment, Reconciliation of Other Items from Segments to Consolidated [Abstract]    
Depreciation expense 1,040 2,230
Additions to intangible assets 15,000  
Segment Assets 144,223 167,526
Stock-based compensation - research & development 7,121 3,234
Stock-based compensation - Selling, general and administrative 25,498 13,795
Journey    
Revenue    
Product revenue, net 55,134 59,662
Other revenue 1,000 19,519
Net revenue 56,134 79,181
Operating expenses    
Cost of goods - product revenue 20,879 22,893
Amortization of acquired intangible assets 3,424 3,767
Research and development 9,857 7,541
Selling, general and administrative 40,204 43,910
Loss recovery (4,553)  
Asset impairment   3,143
Total operating expenses 69,811 81,254
Loss from operations (13,677) (2,073)
Other income (expense)    
Interest Income 757 322
Interest expense and financing fee (2,700) (1,698)
Gain (loss) on common stock warrant liabilities 1,125  
Other income (expense) (116) (183)
Total other income (expense) (934) (1,559)
Loss before income tax expense (14,611) (3,632)
Income tax expense benefit 61 221
Net loss (14,672) (3,853)
Research and development (9,857) (7,541)
Segment, Reconciliation of Other Items from Segments to Consolidated [Abstract]    
Additions to intangible assets 15,000  
Segment Assets 80,241 76,849
Stock-based compensation - research & development 508 110
Stock-based compensation - Selling, general and administrative 5,590 2,496
Avenue    
Operating expenses    
Research and development 6,645 6,131
Research and development - licenses acquired   4,230
Selling, general and administrative 4,638 4,179
Total operating expenses 11,283 14,540
Loss from operations (11,283) (14,540)
Other income (expense)    
Interest Income 176 126
Interest expense and financing fee   (332)
Gain (loss) on common stock warrant liabilities (589) 4,258
Total other income (expense) (413) 4,052
Loss before income tax expense (11,696) (10,488)
Net loss (11,696) (10,488)
Research and development (6,645) (6,131)
Segment, Reconciliation of Other Items from Segments to Consolidated [Abstract]    
Segment Assets 2,672 1,850
Stock-based compensation - research & development 269 199
Stock-based compensation - Selling, general and administrative 967 707
Checkpoint    
Revenue    
Net revenue 41 103
Operating expenses    
Research and development 36,152 43,566
Selling, general and administrative 20,063 8,685
Total operating expenses 56,215 52,251
Loss from operations (56,174) (52,148)
Other income (expense)    
Interest Income 11 84
Gain (loss) on common stock warrant liabilities (73) 217
Other income (expense) (4)  
Total other income (expense) (66) 301
Loss before income tax expense (56,240) (51,847)
Net loss (56,240) (51,847)
Research and development (36,152) (43,566)
Segment, Reconciliation of Other Items from Segments to Consolidated [Abstract]    
Segment Assets 7,471 5,378
Stock-based compensation - research & development 5,248 1,169
Stock-based compensation - Selling, general and administrative 10,004 1,728
Mustang    
Operating expenses    
Research and development 8,418 40,513
Research and development - licenses acquired   527
Selling, general and administrative 4,135 8,220
Asset impairment 3,692  
Total operating expenses 16,245 49,260
Loss from operations (16,245) (49,260)
Other income (expense)    
Interest Income 184 850
Interest expense and financing fee (5) (4,109)
Other income (expense) 314 917
Total other income (expense) 493 (2,342)
Loss before income tax expense (15,752) (51,602)
Net loss (15,752) (51,602)
Research and development (8,418) (40,513)
Segment, Reconciliation of Other Items from Segments to Consolidated [Abstract]    
Depreciation expense 671 1,860
Segment Assets 9,308 17,742
Stock-based compensation - research & development (650) 132
Stock-based compensation - Selling, general and administrative 200 436
Fortress    
Revenue    
Collaboration revenue 1,500 5,229
Net revenue 1,500 5,229
Operating expenses    
Research and development (4,443) 3,996
Research and development - licenses acquired 252 (433)
Selling, general and administrative 18,691 25,987
Total operating expenses 14,500 29,550
Loss from operations (13,000) (24,321)
Other income (expense)    
Interest Income 1,555 1,621
Interest expense and financing fee (10,822) (9,176)
Gain (loss) on common stock warrant liabilities (1,101) (51)
Other income (expense) 1,124 (4,137)
Total other income (expense) (9,244) (11,743)
Loss before income tax expense (22,244) (36,064)
Income tax expense benefit 251 300
Net loss (22,495) (36,364)
Research and development 4,443 (3,996)
Segment, Reconciliation of Other Items from Segments to Consolidated [Abstract]    
Depreciation expense 369 370
Segment Assets 44,531 65,707
Stock-based compensation - research & development 1,746 1,624
Stock-based compensation - Selling, general and administrative 8,737 8,428
Related Party    
Revenue    
Revenue - related party 41 103
Other revenue 1,000 19,519
Related Party | Checkpoint    
Revenue    
Revenue - related party 41 103
Intersegment Eliminations | Avenue    
Operating expenses    
Research and development 329 521
Selling, general and administrative 331 422
Other income (expense)    
Research and development (329) (521)
Intersegment Eliminations | Checkpoint    
Operating expenses    
Research and development 7,638 3,419
Selling, general and administrative 1,495 1,452
Other income (expense)    
Research and development (7,638) (3,419)
Intersegment Eliminations | Mustang    
Operating expenses    
Research and development 861 250
Research and development - licenses acquired   477
Selling, general and administrative 579 364
Other income (expense)    
Research and development (861) (250)
Intersegment Eliminations | Fortress    
Operating expenses    
Research and development (8,828) (4,190)
Research and development - licenses acquired   (477)
Selling, general and administrative (2,405) (2,239)
Other income (expense)    
Research and development $ 8,828 $ 4,190