Annual report [Section 13 and 15(d), not S-K Item 405]

Asset Purchase Agreements (Narrative) (Details)

v3.25.1
Asset Purchase Agreements (Narrative) (Details)
1 Months Ended 12 Months Ended
Jul. 15, 2024
USD ($)
director
Jun. 27, 2024
USD ($)
item
May 13, 2024
Jul. 28, 2023
USD ($)
Apr. 21, 2023
USD ($)
Feb. 24, 2021
USD ($)
Dec. 31, 2024
USD ($)
Jul. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
D
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Feb. 28, 2025
$ / shares
Jul. 31, 2022
USD ($)
Number of days to dispose of assets purchased     180 days                    
Purchase Price recorded in accrued expenses - other             $ 4,915,000   $ 817,000 $ 4,915,000 $ 817,000    
Payments of milestones                   700,000 500,000    
Collaboration revenue                   1,500,000 5,229,000    
Tangible asset impairment charges                     3,100,000    
Asset purchase agreement to acquire Aevitas proprietary rights                          
Fair value of Aevitas interest retained         $ 2,600,000                
Crystalys Therapeutics, Inc                          
Capitalization in equity securities $ 150,000,000                        
Cyprium | Sentynl APA                          
Payments of milestones             1,500,000            
Cyprium | Sentnyl                          
Contingent liability                 4,500,000   4,500,000    
Upfront fees payment           $ 8,000,000     $ 8,000,000        
Collaboration revenue                     700,000    
Avenue | InvaGen                          
Contingent fee payable from proceeds of future financing                         $ 4,000,000
Percentage of contingent fee payable                         7.50%
Aevitas                          
Loss from deconsolidation of Aevitas                     $ (3,400,000)    
Aevitas | Maximum [Member] | Asset purchase agreement to acquire Aevitas proprietary rights                          
Upfront payment to be paid         $ 140,000,000                
Mustang                          
Purchase Price recorded in accrued expenses - other             1,300,000     1,300,000      
Tangible asset impairment charges                   2,600,000      
Mustang | UBriGene                          
Consideration Transferred   $ 1,400,000   $ 6,000,000                  
Consideration Transferred   $ 4,700,000                      
Gain on sale of asset       1,400,000                  
Transaction Related Expenses       $ 300,000                  
Interest rate on outstanding liability   5.00%                      
Upfront payment   $ 100,000           $ 100,000          
Upfront payment due period | item   5                      
Subsequent amount   $ 1,300,000                      
Subsequent payment due period   12 months                      
Purchase Price recorded in accrued expenses - other             1,300,000     1,300,000      
Fair value of assets less cost to sell in repurchase transaction   $ 2,200,000                      
Remaining purchase consideration allocated to the supplies repurchased   2,500,000                      
Fair value of supplies with no alternative future use expensed as research and development expense   2,200,000                      
Fair Value of Supplies With Alternative Future Use Expensed as Research and Development Expense   300,000                      
Aggregate value of assets and associated supplies met the criteria to be classified as held for sale at the date of acquisition   2,200,000         $ 1,200,000     1,200,000      
Outstanding receivable from uBriGene   6,900,000                      
Outstanding payables of the company   3,600,000                      
Net Receivable from uBriGene   3,300,000                      
Urica                          
Percentage of equity to be held 35.00%                        
Urica | Crystalys Therapeutics, Inc                          
Urica's equity position 15.00%                        
Percentage of royalty on future net sales 3.00%                        
Reimbursement of Research and Development $ 600,000                        
Number of directors | director 1                        
Maximum repurchase amount of assets sold under agreements $ 6,400,000                        
Amount of minimum qualified financing required 120,000,000                        
Liability $ 600,000                        
Recorded accretion                   $ 700,000      
SPMA | Cyprium | Sentnyl                          
Number of days to assume control over development of CUTX-101 in the event that CUTX-101 NDA approval has not been obtained                     45    
SPMA | Cyprium | Sentnyl | Manufacturing Services Agreement [Member]                          
Number of days to assume control over development of CUTX-101 in the event that CUTX-101 NDA approval has not been obtained | D                 45        
Subsequent events | Mustang                          
Stock offering, price per share | $ / shares                       $ 3.01  
Net Assets Below 20 Million | Mustang | UBriGene                          
Asset acquisition consideration, threshold net assets considered for delay in subsequent payment   $ 20,000,000                      
Subsequent payment extended due period   6 months                      
FDA approval of the NDA | Cyprium | Sentnyl | Maximum [Member]                          
Payments of milestones           $ 129,000,000              
Annual net sales up to $75 million | Cyprium | Sentynl APA                          
Contingent liability                 $ 75,000,000   $ 75,000,000    
Royalty on net sales to be received (in percent)                 3.00%        
Annual net sales between $75 million and $100 million | Cyprium | Sentynl APA                          
Consideration Transferred                 $ 100,000,000        
Contingent liability                 $ 75,000,000   $ 75,000,000    
Royalty on net sales to be received (in percent)                 8.75%        
Annual net sales in excess of $100 million | Cyprium | Sentynl APA                          
Consideration Transferred                 $ 100,000,000        
Royalty on net sales to be received (in percent)                 12.50%