Licenses Acquired - Additional Information (Detail) - USD ($)
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1 Months Ended |
3 Months Ended |
9 Months Ended |
12 Months Ended |
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May 11, 2015 |
May 31, 2016 |
Feb. 29, 2016 |
Oct. 31, 2015 |
Sep. 30, 2015 |
Jul. 16, 2015 |
Jun. 17, 2015 |
May 31, 2015 |
Apr. 28, 2015 |
Mar. 31, 2015 |
Feb. 28, 2015 |
Sep. 30, 2016 |
Sep. 30, 2015 |
Sep. 30, 2016 |
Sep. 30, 2015 |
Dec. 31, 2015 |
Feb. 17, 2015 |
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payments to Acquire Intangible Assets |
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$ 350,000
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$ 1,250,000
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Research And Development In Process |
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$ 1,000,000
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$ 1,895,000
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3,143,000
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10,882,000
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Stock Issued During Period, Value, Issued for Services |
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2,000
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1,000
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Research And Development Expense |
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7,316,000
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$ 9,073,000
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21,416,000
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$ 13,172,000
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Payments to Acquire in Process Research and Development |
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$ 200,000
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Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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$ 22,600,000
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$ 10,700,000
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Sale Millstone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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7,000,000
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26,200,000
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NeuPharma [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Research And Development In Process |
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$ 1,000,000
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NeuPharma [Member] | Clinical Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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40,000,000
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NeuPharma [Member] | Regulatory Approvals To Commercialize The Products [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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22,500,000
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NeuPharma [Member] | Sale Millstone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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$ 40,000,000
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City Of Hope [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Marketability Percentage Of Invested Capital |
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44.80%
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Payments for Fees |
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$ 2,000,000
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Stock Issued During Period, Shares, Other |
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1,000,000
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Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
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30.00%
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Share Price |
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$ 0.147
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Stock Issued During Period, Value, Other |
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$ 100,000
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City Of Hope [Member] | Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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$ 1,500,000
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City Of Hope [Member] | Sale Millstone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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13,000,000
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National Institutes of Health [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payment of Upfront Milestone Fees |
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700,000
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New Zealand Pharmaceuticals Ltd [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Reimbursement Revenue |
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600,000
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Dana-Farber [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Shares Issued, Price Per Share |
$ 0.065
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Stock Issued During Period, Shares, Issued for Services |
500,000
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136,830
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Stock Issued During Period, Value, Issued for Services |
$ 32,500
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$ 600,000
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Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
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5.00%
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5.00%
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5.00%
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Proceeds from issuance of Common stock |
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$ 10,000,000
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Dana-Farber [Member] | First Commercial Sale Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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21,500,000
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21,500,000
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Dana-Farber [Member] | Additional Sales Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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60,000,000
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60,000,000
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Mustang Bio, Inc [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Research And Development Expense |
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500,000
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$ 1,500,000
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500,000
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1,000,000
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Royalty Guarantees, Commitments, Amount |
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1,000,000
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1,000,000
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Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
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10.00%
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Royalty Revenue |
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300,000
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1,300,000
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Mustang Bio, Inc [Member] | Development Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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$ 14,500,000
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Mustang Bio, Inc [Member] | Financial Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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2,000,000
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Escala Therapeutics, Inc [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payment of Upfront Fees |
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$ 1,300,000
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Teva Pharmaceutical Industries Ltd [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Payment of Upfront Fees |
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$ 500,000
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Teva Pharmaceutical Industries Ltd [Member] | Regulatory Approvals To Commercialize The Products [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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206,500,000
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206,500,000
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Teva Pharmaceutical Industries Ltd [Member] | Clinical Development and Regulatory Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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220,000,000
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220,000,000
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Jubilant Biosys Ltd [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Research And Development In Process |
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2,000,000
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Revenue Recognition Milestone Method, Payments Due |
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87,500,000
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87,500,000
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Payment Of Upfront Licensing Fee |
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$ 2,000,000
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Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
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50.00%
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Jubilant Biosys Ltd [Member] | Regulatory Approvals To Commercialize The Products [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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59,500,000
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Jubilant Biosys Ltd [Member] | Successful Achievement Of One Preclinical Milestone [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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300,000
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300,000
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Jubilant Biosys Ltd [Member] | Completion Of Three Clinical Development Milestones For Two Licensed Products [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
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25,500,000
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25,500,000
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Jubilant Biosys Ltd [Member] | Five Regulatory Approvals And First Commercial Sales [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
|
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|
61,700,000
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61,700,000
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Jubilant Biosys Ltd [Member] | Three Sales Milestones Based On Aggregate Net Sales [Member] |
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Research and Development Arrangement, Contract to Perform for Others [Line Items] |
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Revenue Recognition Milestone Method, Payments Due |
|
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|
|
|
|
|
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|
89,000,000
|
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|
89,000,000
|
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|
Jubilant Biosys Ltd [Member] | Sale Millstone [Member] |
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|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Milestone Method Revenue Additional Payments Eligible To Receive |
|
89,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | Clinical Development and Regulatory Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
$ 89,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Jubilant Biosys Ltd [Member] | TG Therapeutics, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payment Of Upfront Licensing Fee |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1,000,000
|
|
|
|
|
Collaboration Agreement with TGTX [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
|
0
|
|
25,000
|
20,000
|
|
500,000
|
$ 500,000
|
|
Triplex [Member] | City Of Hope [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum Annual Royalty Payable |
|
|
|
|
|
|
|
|
750,000
|
|
|
|
|
|
|
|
|
|
|
Triplex [Member] | City Of Hope [Member] | Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
9,000,000
|
|
|
|
|
|
|
|
|
|
|
Triplex [Member] | City Of Hope [Member] | Sale Millstone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
26,000,000
|
|
|
|
|
|
|
|
|
|
|
Pentameter [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Minimum Annual Royalty Payable |
|
|
|
|
|
|
|
|
750,000
|
|
|
|
|
|
|
|
|
|
|
Pentameter [Member] | City Of Hope [Member] | Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
5,500,000
|
|
|
|
|
|
|
|
|
|
|
Pentameter [Member] | City Of Hope [Member] | Sale Millstone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
26,000,000
|
|
|
|
|
|
|
|
|
|
|
Coronado SO Co, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
|
|
|
$ 0
|
|
$ 0
|
$ 0
|
|
$ 1,607,000
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
$ 900,000
|
|
|
|
|
|
|
|
|
Stock Issued During Period, Shares, Other |
|
|
|
|
|
|
|
|
|
|
150,000
|
|
|
|
|
|
|
|
|
Research And Development Expense |
|
|
|
$ 500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
|
|
13.00%
|
|
|
|
|
|
|
13.00%
|
|
13.00%
|
13.00%
|
|
13.00%
|
|
|
Checkpoint Therapeutics, Inc [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
|
|
|
$ 1,000,000
|
|
$ 600,000
|
$ 3,060,000
|
|
$ 2,633,000
|
|
|
Reimbursement Of Cost Recognized As Revenue |
|
|
|
|
|
|
|
|
|
|
|
$ 251,000
|
|
|
$ 732,000
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
|
|
20.00%
|
|
|
|
|
|
|
62.70%
|
[1] |
20.00%
|
62.70%
|
[1] |
20.00%
|
|
|
Checkpoint Therapeutics, Inc [Member] | First Commercial Sale Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
|
|
|
$ 21,500,000
|
|
|
$ 21,500,000
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Additional Sales Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
|
|
|
60,000,000
|
|
|
60,000,000
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Clinical Development Milestone [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
|
|
|
7,000,000
|
|
|
7,000,000
|
|
|
|
|
Checkpoint Therapeutics, Inc [Member] | Commercial Sales In Specified Territories [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Revenue Recognition Milestone Method, Payments Due |
|
|
|
|
|
|
|
|
|
|
|
14,500,000
|
|
|
14,500,000
|
|
|
|
|
Helocyte [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research And Development In Process |
|
|
|
|
|
|
|
|
200,000
|
|
|
$ 0
|
|
$ 0
|
83,000
|
|
$ 200,000
|
|
|
Research And Development Expense |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 35,000
|
|
|
|
|
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners |
|
|
|
|
|
|
|
|
|
|
|
20.60%
|
|
|
20.60%
|
|
|
|
|
Licensing Agreements [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments to Acquire Intangible Assets |
|
|
$ 35,000
|
|
|
|
|
|
$ 50,000
|
$ 155,000
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | City Of Hope [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketability Percentage Of Invested Capital |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
44.50%
|
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
30.00%
|
|
|
|
|
Share Price |
|
|
|
|
|
|
|
|
|
|
|
$ 0.097
|
|
|
$ 0.097
|
|
|
|
|
Stock Issued During Period, Value, Other |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 48,500
|
|
|
|
|
Licensing Agreements [Member] | City Of Hope [Member] | Common Class A [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncash or Part Noncash Acquisition, Noncash Financial or Equity Instrument Consideration, Shares Issued |
|
500,000
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Dana-Farber [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
$ 1,000,000
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Coronado SO [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Marketability Percentage Of Invested Capital |
|
|
|
44.80%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |
|
|
|
30.00%
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Share Price |
|
|
|
$ 1.19
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | IV Tramadol [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments to Acquire Intangible Assets |
|
|
|
|
|
|
$ 1,000,000
|
|
|
|
|
|
|
|
|
|
|
|
|
Payments for Fees |
|
|
|
|
|
|
|
|
|
|
$ 2,000,000
|
|
|
|
|
|
|
|
|
Licensing Agreements [Member] | Helocyte [Member] | Common Class A [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Noncash or Part Noncash Acquisition, Noncash Financial or Equity Instrument Consideration, Shares Issued |
|
8,333
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Avenue Therapeutics, Inc. [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Research and Development Arrangement, Contract to Perform for Others [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Shares Issued, Price Per Share |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 0.146
|
|
Research And Development Expense |
|
|
|
|
|
|
|
|
|
|
|
$ 2,500
|
|
|
$ 11,500
|
|
|
|
|
Debt Instrument, Fee Amount |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 3,000,000
|
|
|