Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity (Stock Based Compensation) (Narrative) (Details)

v3.21.1
Stockholders' Equity (Stock Based Compensation) (Narrative) (Details) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Jan. 01, 2019
Jan. 01, 2018
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2015
Aug. 27, 2020
Dec. 31, 2018
Dec. 31, 2016
Dec. 31, 2013
Dec. 31, 2007
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, vesting period     10 years              
Stock-based compensation expense     $ 13,451 $ 13,188            
Stock-based compensation expense     $ 13,451 $ 13,188            
Outstanding warrants     4,590,621 2,741,180     2,754,189      
Payments of Stock Issuance Costs     $ 1,658 $ 427            
Proceeds from Issuance of Preferred Stock and Preference Stock     $ 39,075 $ 6,038            
Common Stock, Shares, Outstanding     94,877,492 74,027,425            
Common Stock, Value, Issued     $ 95 $ 74            
Revenue from Contract with Customer, Including Assessed Tax     $ 44,531 34,921            
Consulting Agreements [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights     100,000              
Additional shares     100,000              
Oaktree Note [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights           1,749,450        
Additional shares           1,749,450        
2007 and 2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Share based compensation, number of shares granted     14,721,911              
Stock based compensation, shares available for issuance     4,278,089              
2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, number of shares authorized         13,000,000       2,300,000  
Share based compensation, additional shares authorized     3,000,000   7,700,000          
2012 Employee Stock Purchase Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Predetermined fair value percentage during offering period     85.00%              
Shares purchased in connection with the ESPP offering     577,301              
Number of shares available for future issuance     422,699              
Stock-based compensation expense     $ 100 100            
Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Fair value of stock granted     $ 2,100 600            
LTIP, Percentage of outstanding shares     1.00%              
Long-Term Incentive Program condition, increase in market capitalization     $ 100,000              
Stock-based compensation expense     $ 2,500 1,400            
Maximum [Member] | 2007 and 2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, shares available for issuance               19,000,000    
Maximum [Member] | 2007 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, number of shares authorized                   6,000,000
Chief Executive Officer (Dr. Rosenwald) [Member] | Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted 801,536                  
Executive Vice President (Mr. Weiss) [Member] | Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted   648,204                
Employees and Non-Employees [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     600,000              
Employee Stock Option [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock options, unrecognized compensation expense       0            
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options       0            
Employee Stock Option [Member] | Research and Development Expense [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     $ 3,200 2,800            
Employee Stock Option [Member] | General and Administrative Expense [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     10,300 10,400            
Restricted Stock Awards and Restricted Stock Units [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Fair value of stock granted     2,000 2,000            
Stock-based compensation expense     $ 12,500 $ 11,500            
Restricted Stock [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, vesting period     4 years 1 month 6 days              
Number of shares Granted     1,873,072 1,546,408            
Fair value of stock granted     $ 4,800 $ 1,400            
Unrecognized compensation expense     $ 12,600              
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value     $ 2.57 $ 0.88            
Restricted Stock [Member] | Executives and Directors [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     1,900,000 1,500,000            
Restricted Stock [Member] | Non-Employee Directors [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Deferred compensation plan, shares issued     230,000 230,000            
Restricted Stock [Member] | Employees and Non-Employees [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted       300,000            
Restricted Stock Units (RSUs) [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, vesting period     2 years 9 months 18 days              
Number of shares Granted     630,126 290,000            
Fair value of stock granted     $ 2,400 $ 400            
Unrecognized compensation expense     $ 3,100              
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value     $ 3.82 $ 1.49            
Warrants [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Unrecognized compensation expense     $ 0              
Stock-based compensation expense     $ 130 $ 97            
Performance-based Awards [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     100,000