Annual report pursuant to Section 13 and 15(d)

Licenses Acquired (Mustang - Narrative) (Details)

v3.21.1
Licenses Acquired (Mustang - Narrative) (Details)
€ in Millions, shares in Millions
1 Months Ended 12 Months Ended
Aug. 23, 2019
USD ($)
Aug. 03, 2019
Milestone
Aug. 02, 2018
USD ($)
Milestone
Jan. 03, 2018
USD ($)
Nov. 20, 2017
USD ($)
Milestone
Jul. 03, 2017
USD ($)
May 31, 2017
USD ($)
Milestone
Apr. 25, 2017
USD ($)
Mar. 31, 2017
USD ($)
Milestone
Mar. 17, 2017
USD ($)
Oct. 15, 2015
USD ($)
Oct. 31, 2020
USD ($)
Milestone
Oct. 31, 2020
EUR (€)
Milestone
Mar. 31, 2017
USD ($)
Apr. 30, 2015
USD ($)
Mar. 31, 2015
USD ($)
Milestone
shares
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 $ 2,834,000 $ 6,090,000  
Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 2,489,000 1,350,000  
City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment                             $ 2,000,000.0        
Research and development - licenses acquired                                 334,000 0  
Common shares issued (in shares) | shares                               1.0      
City of Hope (COH) [Member] | Licensing Agreements [Member] | Financial Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Number of financial milestones                               2      
City of Hope (COH) [Member] | Licensing Agreements [Member] | Completion of Clinical Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                               $ 14,500,000      
Number of development milestones | Milestone                               6      
Royalty Guarantees, Commitments, Amount                               $ 1,000,000.0      
CSL Behring [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 170,000 200,000  
University of California [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment               $ 200,000                      
Research and development - licenses acquired                                 0 300,000  
Payments of milestones                                 300,000 0  
University of California [Member] | Licensing Agreements [Member] | Completion of Clinical Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                   $ 14,300,000                  
Nationwide Children's Hospital [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 0 200,000  
Fred Hutchinson Cancer Research Center [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 300,000 0  
Harvard College [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment         $ 300,000                            
Research and development - licenses acquired                                 0 0  
Annual maintenance fee payable                                 100,000 50,000 $ 25,000
Harvard College [Member] | Licensing Agreements [Member] | Achievement of Seven Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones         $ 16,700,000                            
Number of development milestones | Milestone         7                            
SIRION Biotech [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 117,000 0  
MB-102 (CD 123 CAR T for AML) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 334,000 250,000 $ 0
Payments of milestones                                 300,000    
MB-102 (CD 123 CAR T for AML) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Achievement of Certain Sales Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                                 14,500,000    
MB-102 (CD 123 CAR T for AML) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Upon the Twelfth Patient Dosed in a Phase 1 Clinical Study [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                                   300,000  
MB-108 (C134 Oncolytic Virus for GBM [Member] | Nationwide Children's Hospital [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                   200,000  
MB-108 (C134 Oncolytic Virus for GBM [Member] | Nationwide Children's Hospital [Member] | Licensing Agreements [Member] | Achievement of Development and Commercialization Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                                   152,800,000  
MB-104 (CS1 CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment           $ 600,000                          
Research and development - licenses acquired                                 200,000 200,000  
Annual maintenance fee payable                                   50,000  
MB-104 (CS1 CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Achievement of Ten Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                 $ 14,900,000                    
Number of development milestones | Milestone                 10                    
MB-105 (PSCA CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 200,000 200,000  
MB-105 (PSCA CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Achievement of Ten Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Number of development milestones | Milestone             10                        
MB-105 (PSCA CAR T) [Member] | University of California [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment           300,000                          
Research and development - licenses acquired                                 200,000 0  
Annual maintenance fee payable             $ 50,000                        
MB-105 (PSCA CAR T) [Member] | University of California [Member] | Licensing Agreements [Member] | Achievement of Ten Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones             14,900,000                        
MB-106 (Car T Therapy) [Member] | Fred Hutchinson Cancer Research Center [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment           300,000                          
Annual maintenance fee payable           50,000                          
MB-106 (Car T Therapy) [Member] | Fred Hutchinson Cancer Research Center [Member] | First Commercial Sales in Specified Territories [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones           $ 39,100,000                          
MB-106 (Car T Therapy) [Member] | Fred Hutchinson Cancer Research Center [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 300,000 0  
MB-107 (XSCID) [Member] | CSL Behring [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment $ 200,000                                    
Research and development - licenses acquired                                 200,000 200,000  
MB-107 (XSCID) [Member] | CSL Behring [Member] | Licensing Agreements [Member] | Achievement of Development and Commercialization Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones $ 1,200,000                                    
Number of development milestones | Milestone   3                                  
MB-107 (XSCID) [Member] | St Jude Childrens Research Hospital [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment     $ 1,000,000.0                                
Research and development - licenses acquired                                 0 0  
Annual maintenance fee payable     100,000                                
MB-107 (XSCID) [Member] | St Jude Childrens Research Hospital [Member] | Licensing Agreements [Member] | Achievement of Five Development and Commercialization Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones     $ 13,500,000                                
Number of development milestones | Milestone     5                                
MB-103 (HER2 CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment             600,000                        
Research and development - licenses acquired                                 500,000 0  
Annual maintenance fee payable             50,000                        
MB-103 (HER2 CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Achievement of Ten Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones             $ 14,900,000                        
Number of development milestones | Milestone             10                        
MB-103 (HER2 CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Upon the Twelfth Patient Dosed in a Phase 1 Clinical Study [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones             $ 500,000                        
MB-103 (HER2 CAR T) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | First Patient Dosed in a Phase 1 Clinical Study [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                                   200,000  
MB-101 (IL13R2 CAR T for Glioblastoma) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Research and development - licenses acquired                                 334,000 0  
MB-101 (IL13R2 CAR T for Glioblastoma) [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Achievement of Each Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                                 14,500,000    
MB-207 (LentiBOOST) [Member] | SIRION Biotech [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment                       $ 100,000 € 0.1            
Research and development - licenses acquired                                 100,000 0  
MB-207 (LentiBOOST) [Member] | SIRION Biotech [Member] | Licensing Agreements [Member] | Achievement of Five Development Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                       $ 5,600,000 € 4.7            
Number of development milestones | Milestone                       5 5            
MB-207 (LentiBOOST) [Member] | SIRION Biotech [Member] | Licensing Agreements [Member] | Achievement of Three Commercial Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                       $ 4,100,000 € 3.5            
Number of financial milestones | Milestone                       3 3            
Manufacturing License [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment       $ 100,000                              
Research and development - licenses acquired                                 0 0  
Agreement IV/ICV [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Upfront fees payment                           $ 100,000          
Research and development - licenses acquired                                 $ 0 $ 0  
Agreement IV/ICV [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Achievement of Each Milestones [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                           $ 100,000          
Adimab Llc Collaboration Agreement [Member] | Licensing Agreements [Member] | Achievement of Each Milestones [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Payments of milestones                     $ 7,100,000                
Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Percentage of ownership                                 80.90% 70.30%  
Mustang [Member] | City of Hope (COH) [Member] | Licensing Agreements [Member] | Mustang [Member]                                      
Research and Development Arrangement, Contract to Perform for Others [Line Items]                                      
Percentage of ownership                               10.00%