Annual report pursuant to Section 13 and 15(d)

Sponsored Research and Clinical Trial Agreements (Narrative) (Details)

v3.21.1
Sponsored Research and Clinical Trial Agreements (Narrative) (Details)
£ in Millions
1 Months Ended 12 Months Ended
Dec. 16, 2020
USD ($)
Jul. 24, 2018
USD ($)
Mar. 17, 2018
USD ($)
Jan. 25, 2018
USD ($)
Jan. 03, 2018
USD ($)
Nov. 30, 2017
USD ($)
Nov. 28, 2017
USD ($)
Feb. 17, 2017
USD ($)
Mar. 31, 2015
USD ($)
installment
Jan. 31, 2021
USD ($)
Jan. 31, 2021
GBP (£)
Oct. 31, 2020
USD ($)
Jun. 30, 2020
USD ($)
Dec. 31, 2020
USD ($)
Dec. 31, 2019
USD ($)
Dec. 16, 2020
GBP (£)
Nov. 30, 2020
USD ($)
Sep. 30, 2020
USD ($)
May 31, 2020
USD ($)
Jul. 03, 2017
USD ($)
Oct. 31, 2016
USD ($)
Research and development expenses                           $ 64,109,000 $ 81,326,000            
Research and Clinical Trial Agreements [Member] | Aevitas [Member] | AAV Gene Therapies [Member]                                          
Research and development expenses                           948,000 1,133,000            
Research and Clinical Trial Agreements [Member] | Aevitas [Member] | University of Massachusetts [Member]                                          
Sponsored research agreement, funding commitment                                     $ 700,000    
Research and Clinical Trial Agreements [Member] | Aevitas [Member] | University of Massachusetts [Member] | Within 30 days of Execution [Member]                                          
Sponsored research agreement, funding commitment                                     $ 400,000    
Research and Clinical Trial Agreements [Member] | Aevitas [Member] | University of Massachusetts [Member] | AAV Gene Therapies [Member]                                          
Payments for research and development expenses       $ 800,000                                  
Sponsored research agreement, funding commitment       $ 800,000                                  
Research and development expenses                           381,000 0            
Research and Clinical Trial Agreements [Member] | Aevitas [Member] | University of Pennsylvania [Member] | AAV Gene Therapies [Member]                                          
Payments for research and development expenses   $ 300,000                                      
Sponsored research agreement, funding commitment   $ 2,000,000.0                                      
Research and development expenses                           567,000 1,067,000            
Research and Clinical Trial Agreements [Member] | Aevitas [Member] | Duke University School of Medicine [Member] | AAV Gene Therapies [Member]                                          
Research and development expenses                           0 66,000            
Research and Clinical Trial Agreements [Member] | Cellvation [Member] | University of Texas [Member]                                          
Sponsored research agreement, funding commitment                                         $ 800,000
Research and development expenses                           0 100,000            
Research and Clinical Trial Agreements [Member] | Mustang [Member]                                          
Research and development expenses                           7,717,000 6,143,000            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member]                                          
Sponsored research agreement, funding commitment                 $ 2,000,000.0                        
Research and development expenses                           500,000 2,000,000            
Number of installments to pay the upfront fees | installment                 4                        
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-102 (CD 123 CAR T for AML) [Member]                                          
Sponsored research agreement, additional funding commitment               $ 100,000                          
Research and development expenses                           433,000 1,202,000            
Upfront fees payment               20,000                          
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-102 (CD 123 CAR T for AML) [Member] | Over Three Years [Member]                                          
Sponsored research agreement, additional funding commitment               200,000                          
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-104 (CS1 CAR T) [Member]                                          
Research and development expenses                           885,000 0            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-101 (IL13R2 CAR T for Glioblastoma) [Member]                                          
Sponsored research agreement, additional funding commitment               100,000                          
Research and development expenses                           530,000 876,000            
Upfront fees payment               $ 9,300       $ 29,375                  
Payments of milestones                       100,000                  
Funding commitment period               3 years                          
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-101 (IL13R2 CAR T for Glioblastoma) [Member] | Over Three Years [Member]                                          
Research and development expenses               $ 200,000                          
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-101 (IL13R2 CAR T for Glioblastoma) [Member] | Clinical Development and Regulatory Milestones [Member]                                          
Payments of milestones                       200,000                  
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-103 (HER2 CAR T) [Member]                                          
Sponsored research agreement, funding commitment                                   $ 29,375      
Research and development expenses                           1,519,000 0            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-105 (PSCA CAR T) [Member]                                          
Sponsored research agreement, funding commitment                       33,000                  
Research and development expenses                           204,000 0            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | Manufacturing License [Member]                                          
Sponsored research agreement, funding commitment         $ 900,000                                
Research and development expenses                           0 457,000            
Funding commitment period         2 years                                
Research and Clinical Trial Agreements [Member] | Mustang [Member] | City of Hope (COH) [Member] | MB-107 (XSCID) [Member]                                          
Sponsored research agreement, funding commitment                             800,000            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Beth Israel Deaconess Medical Center Inc. [Member] | CRISPR (multiple programs) [Member]                                          
Research and development expenses                           0 69,000            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Beth Israel Deaconess Medical Center Inc. [Member] | CRISPR (multiple programs) [Member] | Over Three Years [Member]                                          
Sponsored research agreement, funding commitment             $ 800,000                            
Funding commitment period             3 years                            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Fred Hutchinson Cancer Research Center [Member] | Manufacturing License [Member]                                          
Payments for research and development expenses     $ 600,000                     0 200,000            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Fred Hutchinson Cancer Research Center [Member] | MB-106 (CD20 CAR T) [Member]                                          
Research and development expenses                           1,804,000 762,000            
Research and Clinical Trial Agreements [Member] | Mustang [Member] | St. Jude Children's Research Hospital [Member] | MB-107 (XSCID) [Member]                                          
Research and development expenses                           1,842,000 777,000            
Upfront fees payment                         $ 1,100,000                
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Maximum [Member] | City of Hope (COH) [Member] | MB-104 (CS1 CAR T) [Member]                                          
Sponsored research agreement, funding commitment                         $ 2,400,000                
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Maximum [Member] | City of Hope (COH) [Member] | MB-103 (HER2 CAR T) [Member]                                          
Sponsored research agreement, funding commitment                                   $ 3,000,000.0      
Research and Clinical Trial Agreements [Member] | Mustang [Member] | Maximum [Member] | City of Hope (COH) [Member] | MB-105 (PSCA CAR T) [Member]                                          
Sponsored research agreement, funding commitment                       $ 2,300,000                  
Research and Clinical Trial Agreements [Member] | Oncogenuity [Member] | Columbia University [Member]                                          
Research and development expenses                           $ 500,000 0            
Funding commitment period                           5 years              
Research and Clinical Trial Agreements [Member] | Oncogenuity [Member] | University of Oxford [Member]                                          
Funding commitment period 18 months                                        
Research and Clinical Trial Agreements [Member] | Oncogenuity [Member] | University of Oxford [Member] | Subsequent Events [Member]                                          
Upfront fees payment                   $ 100,000 £ 0.1                    
Research and Clinical Trial Agreements [Member] | Oncogenuity [Member] | Maximum [Member] | Columbia University [Member]                                          
Sponsored research agreement, funding commitment                           $ 4,800,000              
Research and Clinical Trial Agreements [Member] | Oncogenuity [Member] | Maximum [Member] | University of Oxford [Member]                                          
Sponsored research agreement, funding commitment $ 600,000                             £ 0.4          
Research and Clinical Trial Agreements [Member] | Tamid [Member] | University of North Carolina [Member]                                          
Research and development expenses                           0 0            
Upfront fees payment           $ 800,000                              
Research and Clinical Trial Agreements [Member] | Tamid [Member] | University of North Carolina [Member] | Over Three Years [Member]                                          
Sponsored research agreement, funding commitment           $ 2,300,000                              
Funding commitment period           3 years                              
Clinical Trial Agreements [Member] | Mustang [Member] | Fred Hutchinson Cancer Research Center [Member] | MB-106 (CD20 CAR T) [Member]                                          
Sponsored research agreement, additional funding commitment                                 $ 800,000        
Research and development expenses                           $ 1,800,000 $ 600,000            
Clinical Trial Agreements [Member] | Mustang [Member] | Maximum [Member] | Fred Hutchinson Cancer Research Center [Member] | MB-106 (CD20 CAR T) [Member]                                          
Sponsored research agreement, funding commitment                                       $ 5,300,000