Debt (Details Textual) (USD $)
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1 Months Ended | 12 Months Ended | 78 Months Ended | 0 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 0 Months Ended | 12 Months Ended | |||||||||||||||||||||||
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Aug. 31, 2012
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Sep. 30, 2010
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Dec. 31, 2012
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Dec. 31, 2011
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Dec. 31, 2010
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Dec. 31, 2012
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Aug. 16, 2012
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Jan. 07, 2011
Asphelia Asset Purchase [Member]
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Dec. 31, 2010
Series A [Member]
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Dec. 31, 2012
Warrants [Member]
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Dec. 31, 2011
Warrants [Member]
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Dec. 31, 2010
Warrants [Member]
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Aug. 31, 2012
Hercules debt agreement [Member]
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Dec. 31, 2012
Hercules debt agreement [Member]
Installment
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Dec. 31, 2012
Hercules debt agreement [Member]
Estimate of fair value, fair value disclosure [Member]
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Dec. 31, 2012
Hercules debt agreement [Member]
Warrants [Member]
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Feb. 28, 2010
Related Party Notes [Member]
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Jan. 31, 2010
Related Party Notes [Member]
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Jul. 31, 2009
Related Party Notes [Member]
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Sep. 30, 2008
Related Party Notes [Member]
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Dec. 31, 2012
Related Party Notes [Member]
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Dec. 31, 2010
Related Party Notes [Member]
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Jan. 31, 2010
Related Party Notes [Member]
Series A Common Stock [Member]
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Dec. 31, 2012
Related Party Notes [Member]
Series A Common Stock [Member]
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Dec. 31, 2012
Related Party Notes [Member]
Individual stockholder and Trust [Member]
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Dec. 31, 2012
Related Party Notes [Member]
Stockholders Family Members [Member]
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Dec. 31, 2012
Related Party Notes [Member]
Payable to PBS [Member]
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Dec. 31, 2009
PCP Promissory Notes [Member]
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Dec. 31, 2010
PCP Promissory Notes [Member]
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Jan. 07, 2011
PCP Promissory Notes [Member]
Asphelia Asset Purchase [Member]
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Dec. 31, 2009
PCP Promissory Notes [Member]
Warrants [Member]
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Dec. 31, 2012
2008 Senior Convertible Notes [Member]
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Dec. 31, 2008
2008 Senior Convertible Notes [Member]
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Dec. 31, 2009
2009 Senior Convertible Notes [Member]
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Dec. 31, 2012
Senior Convertible Notes [Member]
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Dec. 31, 2010
Senior Convertible Notes [Member]
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Dec. 31, 2010
Senior Convertible Notes [Member]
Series A [Member]
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Debt (Textual) [Abstract] | |||||||||||||||||||||||||||||||||||||
Term loan | $ 15,000,000 | ||||||||||||||||||||||||||||||||||||
Received net proceeds | 14,700,000 | 570,000 | 750,000 | ||||||||||||||||||||||||||||||||||
Interest rate | interest at a rate per annum equal to the greater of (i) 9.25% or (ii) 9.25% plus the sum of the prevailing prime rate minus 3.25% | ||||||||||||||||||||||||||||||||||||
Loan bears interest at a rate per annum | 9.25% | 8.00% | 10.00% | 10.00% | 8.00% | 8.00% | |||||||||||||||||||||||||||||||
Deduction rate on loan bears interest at a rate per annum | 3.25% | ||||||||||||||||||||||||||||||||||||
Maturity Date | Mar. 01, 2016 | Sep. 30, 2010 | Feb. 20, 2010 | ||||||||||||||||||||||||||||||||||
Interest payment term | interest-only payments for the initial 12 months and thereafter repay the principal balance of the loan with interest in 30 monthly installments. | ||||||||||||||||||||||||||||||||||||
No of Loan repayment installments after 12 month | 30 | ||||||||||||||||||||||||||||||||||||
Interest only period Contingent upon achievement of certain clinical development milestone | 6 months | ||||||||||||||||||||||||||||||||||||
Number of Loan repayment consists of interest installments before 12 month | 12 | ||||||||||||||||||||||||||||||||||||
Subsequent private placement | 2,000,000 | ||||||||||||||||||||||||||||||||||||
Warrant period | 7 years | ||||||||||||||||||||||||||||||||||||
Warrant to purchase common stock | 20,000 | 73,009 | 27,175 | ||||||||||||||||||||||||||||||||||
Increase Warrants pursuant to an anti-dilution | 3,371,161 | 10,206,543 | 3,498,114 | 1,091,558 | 804,949 | 261,860 | 40,787 | ||||||||||||||||||||||||||||||
Cash Commissions percentage of gross proceeds | 2.00% | ||||||||||||||||||||||||||||||||||||
Warrant exercise price | 5.72 | 5.65 | |||||||||||||||||||||||||||||||||||
Fair value of the warrant contractual term | 6 years | 7 years | |||||||||||||||||||||||||||||||||||
Fair value of the warrant volatility | 104.51% | 87.20% | |||||||||||||||||||||||||||||||||||
Fair value of risk-free interest rate | 1.06% | 1.10% | |||||||||||||||||||||||||||||||||||
Dividend yield | 0.00% | 0.00% | |||||||||||||||||||||||||||||||||||
Approximate fair value of the warrant | 14,800,000 | 14,800,000 | 323,000 | ||||||||||||||||||||||||||||||||||
Charges on termination of the loan stated percentage | 2.65% | ||||||||||||||||||||||||||||||||||||
Charges on termination of the loan, amount | 398,000 | ||||||||||||||||||||||||||||||||||||
Fees related to the loan agreement | 218,000 | 800,000 | |||||||||||||||||||||||||||||||||||
Interest rate for amortize loan discounts | 12.30% | ||||||||||||||||||||||||||||||||||||
Interest expense related to the Hercules loan | 670,000 | 74,000 | 1,535,000 | 3,953,000 | 609,000 | ||||||||||||||||||||||||||||||||
Interest expenses accretion of debt discounts | 123,000 | ||||||||||||||||||||||||||||||||||||
Term of debt instrument periodic payment | 12 months | ||||||||||||||||||||||||||||||||||||
Current portion of note payable | 1,799,000 | 1,799,000 | 1,799,000 | ||||||||||||||||||||||||||||||||||
Non Current portion of notes payable | 12,386,000 | 12,386,000 | |||||||||||||||||||||||||||||||||||
2015 | 6,300,000 | 6,300,000 | |||||||||||||||||||||||||||||||||||
2013 | 1,800,000 | 1,800,000 | |||||||||||||||||||||||||||||||||||
2014 | 5,750,000 | 5,750,000 | |||||||||||||||||||||||||||||||||||
2016 | 1,140,000 | 1,140,000 | |||||||||||||||||||||||||||||||||||
Paid off to its related party | 61,000 | ||||||||||||||||||||||||||||||||||||
Repaid the principal amount of accrued interest | 600,000 | ||||||||||||||||||||||||||||||||||||
Promissory note maturity period | 3 years | 4 years | |||||||||||||||||||||||||||||||||||
Promissory note issuance date | Jan. 17, 2008 | Jun. 28, 2006 | Jul. 30, 2007 | ||||||||||||||||||||||||||||||||||
Common stock conversion price equal to lowest price paid by investors | 100.00% | 7.50% | |||||||||||||||||||||||||||||||||||
Debt discount recorded | 815,000 | 815,000 | 100,000 | ||||||||||||||||||||||||||||||||||
Qualified equity financing amount | 10,000,000 | ||||||||||||||||||||||||||||||||||||
Related party notes, principal and accrued interest | 300,000 | 1,600,000 | |||||||||||||||||||||||||||||||||||
Convertible Preferred stock number of preferred stock converted into common stock | 36,194 | 273,046 | |||||||||||||||||||||||||||||||||||
Aggregate consideration payable | 20,706,000 | ||||||||||||||||||||||||||||||||||||
Cash proceeds from Senior Convertible Notes | 3,500,000 | ||||||||||||||||||||||||||||||||||||
Cash proceeds from 2008 Senior Convertible Notes | 4,100,000 | ||||||||||||||||||||||||||||||||||||
Due date of Senior Convertible Note | Feb. 20, 2009 | Feb. 20, 2010 | |||||||||||||||||||||||||||||||||||
Extended Maturity date | Feb. 20, 2010 | Sep. 30, 2010 | |||||||||||||||||||||||||||||||||||
Increased Interest rate | 0.10 | ||||||||||||||||||||||||||||||||||||
Options to extended maturity period | 1 year | ||||||||||||||||||||||||||||||||||||
Interest Expense on estimated life | 2 years | ||||||||||||||||||||||||||||||||||||
Debt Discount | 700,000 | 939,000 | |||||||||||||||||||||||||||||||||||
Repayment Premium, Percentage | 42.90% | ||||||||||||||||||||||||||||||||||||
Principal and accrued interest total | 8,600,000 | ||||||||||||||||||||||||||||||||||||
Senior convertible notes converted to shares | 1,464,479 | ||||||||||||||||||||||||||||||||||||
Share per price | $ 5.87 | $ 8.39 | $ 5.87 | ||||||||||||||||||||||||||||||||||
Repayment Premium | $ 600,000 | ||||||||||||||||||||||||||||||||||||
Commission as percentage of gross proceeds | 7.00% |