Quarterly report pursuant to Section 13 or 15(d)

Collaboration and Stock Purchase Agreements (Narrative) (Details)

v3.21.2
Collaboration and Stock Purchase Agreements (Narrative) (Details) - USD ($)
$ / shares in Units, $ in Thousands, shares in Millions
3 Months Ended 6 Months Ended
Feb. 24, 2021
Feb. 08, 2019
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Cash and cash equivalents     $ 274,992 $ 183,278 $ 274,992 $ 183,278 $ 233,351
Collaboration revenue     2,400 $ 0 3,200 0  
Accumulated deficit     (495,117)   (495,117)   $ (482,760)
Cyprium [Member] | Sentynl Therapeutics, Inc [Member]              
Upfront fees payment $ 8,000            
Payments of milestones $ 12,000            
Percentage of ownership over any FDA priority review voucher 100.00%            
Collaboration revenue     2,400   3,200 $ 0  
Avenue [Member]              
Cash and cash equivalents     1,100   1,100    
Accumulated deficit     $ (75,200)   (75,200)    
SPMA [Member] | Minimum [Member] | Avenue [Member] | InvaGen [Member]              
Percentage of common shares acquired in the Stock Purchase Transaction for the rights to exist   75.00%          
SPMA [Member] | Maximum [Member] | Avenue [Member] | InvaGen [Member]              
Business Combination, possible Interim financing   $ 7,000          
FDA approval of the NDA [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]              
Payments of milestones $ 9,000            
Achievement of Certain Sales Milestones [Member] | Maximum [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]              
Payments of milestones 255,000            
Strategic Transaction, First Stage [Member] | SPMA [Member] | Avenue [Member] | InvaGen [Member]              
Sale of stock, number of shares issued   5.8          
Sale of stock, price per share   $ 6.00          
Sale of Stock, Consideration Received on Transaction   $ 35,000          
Sale of stock, ownership percentage after the transaction   33.30%          
Strategic Transaction, Second Stage [Member] | SPMA [Member] | Avenue [Member] | InvaGen [Member]              
Sale of Stock, Consideration Received on Transaction   $ 180,000          
Completion of Clinical Development Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]              
Payments of milestones $ 3,000            
IV Tramadol [Member] | FDA approval of the NDA [Member] | Avenue [Member]              
Payments of milestones         $ 5,000