Condensed Consolidated Statement of Changes in Stockholders' Equity - USD ($) $ in Thousands |
Series A Preferred Stock [Member] |
Common Stock [Member] |
Shares Issuable [Member] |
Paid-In Capital [Member] |
Accumulated Deficit [Member] |
Non-Controlling Interests [Member] |
Total |
Balance at Dec. 31, 2017 |
$ 1
|
$ 51
|
$ 500
|
$ 364,148
|
$ (312,127)
|
$ 67,929
|
$ 120,502
|
Balance (in shares) at Dec. 31, 2017 |
1,000,000
|
50,991,285
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
7,947
|
|
|
7,947
|
Issuance of restricted stock |
|
$ 2
|
|
(2)
|
|
|
|
Issuance of restricted stock (in shares) |
|
1,558,274
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
128
|
|
|
128
|
Issuance of common stock under ESPP (in shares) |
|
43,707
|
|
|
|
|
|
Issuance of subsidiaries' common shares for license expenses |
|
|
|
23
|
|
|
23
|
Issuance of common stock for at-the-market offering, net |
|
$ 1
|
|
4,069
|
|
|
4,070
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
1,130,835
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
(1,172)
|
|
|
(1,172)
|
Partner company's offering, net |
|
|
|
22,657
|
|
|
22,657
|
Common shares issuable for 2017 Subordinated Note Financing interest expense |
|
|
489
|
|
|
|
489
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
|
(500)
|
989
|
|
|
489
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
262,973
|
|
|
|
|
|
Common shares issued for Opus interest expense |
|
|
287
|
|
|
|
287
|
Exercise of subsidiary's warrants for cash |
|
|
|
181
|
|
|
181
|
At-the-market offering cost |
|
|
|
(141)
|
|
|
(141)
|
2017 Preferred A offering cost adjustment |
|
|
|
1,297
|
|
|
1,297
|
Disposal of National |
|
|
|
13,442
|
|
|
13,442
|
Non-controlling interest in subsidiaries |
|
|
|
(15,708)
|
|
15,708
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
(31,305)
|
(31,305)
|
Net income (loss) attributable to common stockholders |
|
|
|
|
(42,629)
|
|
(42,629)
|
Balance at Jun. 30, 2018 |
$ 1
|
$ 54
|
776
|
397,858
|
(354,756)
|
52,332
|
96,265
|
Balance (in shares) at Jun. 30, 2018 |
1,000,000
|
53,987,074
|
|
|
|
|
|
Balance at Dec. 31, 2017 |
$ 1
|
$ 51
|
500
|
364,148
|
(312,127)
|
67,929
|
120,502
|
Balance (in shares) at Dec. 31, 2017 |
1,000,000
|
50,991,285
|
|
|
|
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
|
(57,789)
|
Balance at Dec. 31, 2018 |
$ 1
|
$ 58
|
659
|
397,408
|
(396,274)
|
17,891
|
19,743
|
Balance (in shares) at Dec. 31, 2018 |
1,000,000
|
57,845,447
|
|
|
|
|
|
Balance at Mar. 31, 2018 |
$ 1
|
$ 52
|
489
|
374,254
|
(333,145)
|
65,895
|
107,546
|
Balance (in shares) at Mar. 31, 2018 |
1,000,000
|
52,686,537
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
3,152
|
|
|
3,152
|
Issuance of restricted stock |
|
$ 1
|
|
(1)
|
|
|
|
Issuance of restricted stock (in shares) |
|
85,834
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
128
|
|
|
128
|
Issuance of common stock under ESPP (in shares) |
|
43,707
|
|
|
|
|
|
Issuance of subsidiaries' common shares for license expenses |
|
|
|
1
|
|
|
1
|
Issuance of common stock for at-the-market offering, net |
|
$ 1
|
|
3,751
|
|
|
3,752
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
1,066,038
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
(586)
|
|
|
(586)
|
Partner company's offering, net |
|
|
|
1,813
|
|
|
1,813
|
Common shares issuable for 2017 Subordinated Note Financing interest expense |
|
|
489
|
|
|
|
489
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
|
(489)
|
489
|
|
|
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
104,958
|
|
|
|
|
|
Common shares issued for Opus interest expense |
|
|
287
|
|
|
|
287
|
Exercise of subsidiary's warrants for cash |
|
|
|
85
|
|
|
85
|
At-the-market offering cost |
|
|
|
(135)
|
|
|
(135)
|
2017 Preferred A offering cost adjustment |
|
|
|
1,297
|
|
|
1,297
|
Disposal of National |
|
|
|
14,152
|
|
|
14,152
|
Non-controlling interest in subsidiaries |
|
|
|
(542)
|
|
542
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
(14,105)
|
(14,105)
|
Net income (loss) attributable to common stockholders |
|
|
|
|
(21,611)
|
|
(21,611)
|
Balance at Jun. 30, 2018 |
$ 1
|
$ 54
|
776
|
397,858
|
(354,756)
|
52,332
|
96,265
|
Balance (in shares) at Jun. 30, 2018 |
1,000,000
|
53,987,074
|
|
|
|
|
|
Balance at Dec. 31, 2018 |
$ 1
|
$ 58
|
659
|
397,408
|
(396,274)
|
17,891
|
19,743
|
Balance (in shares) at Dec. 31, 2018 |
1,000,000
|
57,845,447
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
6,682
|
|
|
6,682
|
Issuance of restricted stock |
|
$ 2
|
|
(2)
|
|
|
|
Issuance of restricted stock (in shares) |
|
1,664,742
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
60
|
|
|
60
|
Issuance of common stock under ESPP (in shares) |
|
54,221
|
|
|
|
|
|
Issuance of subsidiaries' common shares for license expenses |
|
|
(164)
|
164
|
|
|
|
Issuance of common stock for at-the-market offering, net |
|
$ 8
|
|
13,859
|
|
|
13,867
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
7,390,826
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
(1,172)
|
|
|
(1,172)
|
Partner company's offering, net |
|
|
|
60,984
|
|
|
60,984
|
Partner company's at-the-market offering, net |
|
|
|
26,339
|
|
|
26,339
|
Issuance of partner company warrants in conjunction with Horizon Notes |
|
|
|
888
|
|
|
888
|
Common shares issuable for 2017 Subordinated Note Financing interest expense |
|
|
490
|
|
|
|
490
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
|
(495)
|
979
|
|
|
484
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
1,012,646
|
|
|
|
|
|
Common shares issuable for Opus interest expense |
|
|
281
|
|
|
|
281
|
Common shares issued for Opus interest expense |
|
|
(281)
|
341
|
|
|
60
|
Common shares issued for Opus interest expense (in shares) |
|
170,321
|
|
|
|
|
|
Non-controlling interest in subsidiaries |
|
|
|
(67,235)
|
|
67,235
|
|
Deconsolidation of Caelum non-controlling interest |
|
|
|
|
|
4,849
|
4,849
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
(32,029)
|
(32,029)
|
Net income (loss) attributable to common stockholders |
|
|
|
|
(11,706)
|
|
(11,706)
|
Balance at Jun. 30, 2019 |
$ 1
|
$ 68
|
490
|
439,295
|
(407,980)
|
57,946
|
89,820
|
Balance (in shares) at Jun. 30, 2019 |
1,000,000
|
68,138,203
|
|
|
|
|
|
Balance at Mar. 31, 2019 |
$ 1
|
$ 63
|
765
|
414,870
|
(394,882)
|
29,892
|
50,709
|
Balance (in shares) at Mar. 31, 2019 |
1,000,000
|
63,126,521
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
3,373
|
|
|
3,373
|
Issuance of restricted stock (in shares) |
|
55,417
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
60
|
|
|
60
|
Issuance of common stock under ESPP (in shares) |
|
54,221
|
|
|
|
|
|
Issuance of common stock for at-the-market offering, net |
|
$ 5
|
|
7,720
|
|
|
7,725
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
4,463,399
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
(586)
|
|
|
(586)
|
Partner company's offering, net |
|
|
|
29,485
|
|
|
29,485
|
Partner company's at-the-market offering, net |
|
|
|
25,984
|
|
|
25,984
|
Common shares issuable for 2017 Subordinated Note Financing interest expense |
|
|
490
|
|
|
|
490
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
|
(484)
|
484
|
|
|
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
268,324
|
|
|
|
|
|
Common shares issued for Opus interest expense |
|
|
(281)
|
341
|
|
|
60
|
Common shares issued for Opus interest expense (in shares) |
|
170,321
|
|
|
|
|
|
Non-controlling interest in subsidiaries |
|
|
|
(42,436)
|
|
42,436
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
(14,382)
|
(14,382)
|
Net income (loss) attributable to common stockholders |
|
|
|
|
(13,098)
|
|
(13,098)
|
Balance at Jun. 30, 2019 |
$ 1
|
$ 68
|
$ 490
|
$ 439,295
|
$ (407,980)
|
$ 57,946
|
$ 89,820
|
Balance (in shares) at Jun. 30, 2019 |
1,000,000
|
68,138,203
|
|
|
|
|
|