Quarterly report pursuant to Section 13 or 15(d)

Fair Value Measurements - Changes in Fair Value of Financial Instruments (Detail)

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Fair Value Measurements - Changes in Fair Value of Financial Instruments (Detail) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2017
Sep. 30, 2016
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance $ 20,941  
Additions during the period 10,139  
Conversion into common shares (1,064)  
Issuance of warrants 0  
Loss on write off investment (250) $ 0
Change in fair value of investments (241)  
Change in fair value of convertible notes 359  
Change in fair value of derivative liabilities (5,155)  
Balance 24,729  
Contingently Issuable Warrant [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 14,661  
Additions during the period 0  
Conversion into common shares (750)  
Issuance of warrants (8,190)  
Loss on write off investment 0  
Change in fair value of investments 0  
Change in fair value of convertible notes 0  
Change in fair value of derivative liabilities (5,079)  
Balance 642  
Helocyte Convertible Note At Fair Value [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 4,487  
Additions during the period 0  
Conversion into common shares 0  
Issuance of warrants 0  
Loss on write off investment 0  
Change in fair value of investments 0  
Change in fair value of convertible notes 246  
Change in fair value of derivative liabilities 0  
Balance 4,733  
Avenue Convertible Note, at fair value [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 200  
Additions during the period 0  
Conversion into common shares (299)  
Issuance of warrants 0  
Loss on write off investment 0  
Change in fair value of investments 0  
Change in fair value of convertible notes 99  
Change in fair value of derivative liabilities 0  
Balance 0  
Caelum Convertible Notes [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 0  
Additions during the period 9,914  
Conversion into common shares 0  
Issuance of warrants 0  
Loss on write off investment 0  
Change in fair value of investments 0  
Change in fair value of convertible notes 14  
Change in fair value of derivative liabilities 0  
Balance 9,928  
Warrant liabilities [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 179  
Additions during the period 225  
Conversion into common shares (15)  
Issuance of warrants 8,190  
Loss on write off investment 0  
Change in fair value of investments 0  
Change in fair value of convertible notes 0  
Change in fair value of derivative liabilities (76)  
Balance 8,503  
Investment In Laser Device [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 250  
Additions during the period 0  
Conversion into common shares 0  
Issuance of warrants 0  
Loss on write off investment (250)  
Change in fair value of investments 0  
Change in fair value of convertible notes 0  
Change in fair value of derivative liabilities 0  
Balance 0  
Investment In Origo [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 1,164  
Additions during the period 0  
Conversion into common shares 0  
Issuance of warrants 0  
Loss on write off investment 0  
Change in fair value of investments (241)  
Change in fair value of convertible notes 0  
Change in fair value of derivative liabilities 0  
Balance $ 923