Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity (Narrative) (Details)

v3.22.1
Stockholders' Equity (Narrative) (Details) - USD ($)
$ in Thousands
12 Months Ended
Jan. 01, 2022
Nov. 12, 2021
Jan. 01, 2021
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2015
Aug. 27, 2020
Dec. 31, 2016
Dec. 31, 2013
Dec. 31, 2007
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       $ 19,486 $ 13,451          
Stock options, unrecognized compensation expense         0          
Stock based compensation, vesting period       10 years            
Journey [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       $ 2,466 153          
Journey [Member] | 8% Cumulative Convertible Class A Preferred Stock [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of common stocks converted from preferred stocks   2,231,346                
Consulting Agreements [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights       100,000            
Oaktree Note [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Class of Warrant or Right, Number of Securities Called by Warrants or Rights             1,749,450      
Warrants, fair value             $ 4,400      
2007 and 2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Share based compensation, number of shares granted       16,506,003            
Stock based compensation, shares available for issuance       2,493,997            
2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, number of shares authorized           13,000,000     2,300,000  
Share based compensation, additional shares authorized       3,000,000   7,700,000        
2012 Employee Stock Purchase Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       $ 100 100          
Predetermined fair value percentage during offering period       85.00%            
Shares purchased in connection with the ESPP offering       694,729            
Number of shares available for future issuance       305,271            
Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       $ 3,800 2,500          
Fair value of stock granted       $ 2,800 3,300          
LTIP, Percentage of outstanding shares       1.00%            
Long-Term Incentive Program condition, increase in market capitalization       $ 100,000            
Maximum [Member] | 2007 and 2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, shares available for issuance               19,000,000    
Maximum [Member] | 2007 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, number of shares authorized                   6,000,000
Chief Executive Officer (Dr. Rosenwald) [Member] | Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted 1,102,986                  
Executive Vice President (Mr. Weiss) [Member] | Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     1,030,339              
Employees and Non-Employees [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted       1,400,000            
Research and Development Expense [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       $ 4,300 3,200          
General and Administrative Expense [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       15,200 10,300          
Restricted Stock Awards and Restricted Stock Units [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       19,500 12,500          
Fair value of stock granted       3,500 $ 2,000          
Restricted Stock [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Unrecognized compensation expense for awards other than options       $ 19,400            
Number of shares Granted       2,330,678 1,873,072          
Stock based compensation, vesting period       3 years 2 months 12 days            
Fair value of stock granted       $ 7,400 $ 4,800          
Restricted Stock [Member] | Executives and Directors [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted       2,300,000 1,900,000          
Restricted Stock [Member] | Non-Employee Directors [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Deferred compensation plan, shares issued       230,000 230,000          
Restricted Stock [Member] | Employees and Non-Employees [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted         600,000          
Restricted Stock Units (RSUs) [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Unrecognized compensation expense for awards other than options       $ 4,300            
Number of shares Granted       1,405,842 630,126          
Stock based compensation, vesting period       2 years 1 month 6 days            
Fair value of stock granted       $ 5,500 $ 2,400          
Warrants to Purchase Common Stock [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       0 $ 130          
Unrecognized compensation expense for awards other than options       $ 0            
Performance-based Awards [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted       100,000