Quarterly report pursuant to Section 13 or 15(d)

Debt and Interest - Schedule of Interest Expenses for Debt Arrangements (Detail)

v3.4.0.3
Debt and Interest - Schedule of Interest Expenses for Debt Arrangements (Detail) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2016
Mar. 31, 2015
Debt [Line Items]    
Interest expense related to the Hercules loan $ 620 $ 331
LOC Fees [Member]    
Debt [Line Items]    
Interest 4 2
Interest and Debt Expense, Total 4 2
IDB Note [Member]    
Debt [Line Items]    
Interest 80 69
Amortization of fees 1 1
Interest and Debt Expense, Total 81 70
NSC Debt [Member]    
Debt [Line Items]    
Interest 167 72
Amortization of fees 368 20
Interest and Debt Expense, Total 535 92
Ovamed [Member]    
Debt [Line Items]    
Interest 0 167
Interest and Debt Expense, Total $ 0 $ 167