Condensed Consolidated Statement of Changes in Stockholders' Equity - USD ($) $ in Thousands |
Series A Preferred Stock [Member] |
Common Stock [Member] |
Shares Issuable [Member] |
Treasury Stock [Member] |
Paid-In Capital [Member] |
Accumulated Deficit [Member] |
Non-Controlling Interests [Member] |
Total |
Balance at Dec. 31, 2018 |
$ 1
|
$ 58
|
$ 659
|
|
$ 397,408
|
$ (396,274)
|
$ 17,891
|
$ 19,743
|
Balance (in shares) at Dec. 31, 2018 |
1,000,000
|
57,845,447
|
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
|
10,423
|
|
|
10,423
|
Issuance of restricted stock |
|
$ 2
|
|
|
(2)
|
|
|
|
Issuance of restricted stock (in shares) |
|
1,842,034
|
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
|
60
|
|
|
60
|
Issuance of common stock under ESPP (in shares) |
|
54,221
|
|
|
|
|
|
|
Issuance of subsidiaries' common shares for license expenses |
|
|
(164)
|
|
164
|
|
|
|
Issuance of common stock for at-the-market offering, net |
|
$ 9
|
|
|
15,789
|
|
|
15,798
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
8,604,469
|
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
|
(1,773)
|
|
|
(1,773)
|
Partner company's sale of stock, net |
|
|
|
|
61,036
|
|
|
61,036
|
Partner company's at-the-market offering, net |
|
|
|
|
29,680
|
|
|
29,680
|
Issuance of partner company warrants in conjunction with Horizon Notes |
|
|
|
|
888
|
|
|
888
|
Common shares issuable for 2017 Subordinated Note Financing interest expense |
|
|
500
|
|
|
|
|
500
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
$ 1
|
(495)
|
|
1,468
|
|
|
974
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
1,330,450
|
|
|
|
|
|
|
Common shares issuable for 2019 Notes interest expense |
|
|
281
|
|
|
|
|
281
|
Common shares issued for 2019 Notes interest expense |
|
|
(281)
|
|
506
|
|
|
225
|
Common shares issued for 2019 Notes interest expense (in shares) |
|
262,088
|
|
|
|
|
|
|
Common shares issued for Opus debt |
|
|
|
|
500
|
|
|
500
|
Common shares issued for Opus debt (in shares) |
|
396,825
|
|
|
|
|
|
|
Non-controlling interest in subsidiaries |
|
|
|
|
(70,702)
|
|
70,702
|
|
Deconsolidation of Caelum non-controlling interest |
|
|
|
|
|
|
4,849
|
4,849
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
|
(44,237)
|
(44,237)
|
Net loss attributable to common stockholders |
|
|
|
|
|
(24,468)
|
|
(24,468)
|
Issuance of preferred A for at-the-market offering, net |
|
|
|
|
523
|
|
|
523
|
Issuance of preferred A for at-the-market offering, net (in shares) |
26,111
|
|
|
|
|
|
|
|
Write off of Partner company note receivable |
|
|
|
|
(2)
|
|
|
(2)
|
Balance at Sep. 30, 2019 |
$ 1
|
$ 70
|
500
|
|
445,966
|
(420,742)
|
49,205
|
75,000
|
Balance (in shares) at Sep. 30, 2019 |
1,026,111
|
70,335,534
|
|
|
|
|
|
|
Balance at Jun. 30, 2019 |
$ 1
|
$ 68
|
490
|
|
439,295
|
(407,980)
|
57,946
|
89,820
|
Balance (in shares) at Jun. 30, 2019 |
1,000,000
|
68,138,203
|
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
|
3,741
|
|
|
3,741
|
Issuance of restricted stock (in shares) |
|
177,292
|
|
|
|
|
|
|
Issuance of common stock for at-the-market offering, net |
|
$ 1
|
|
|
1,930
|
|
|
1,931
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
1,213,643
|
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
|
(601)
|
|
|
(601)
|
Partner company's offering, net |
|
|
|
|
52
|
|
|
52
|
Partner company's at-the-market offering, net |
|
|
|
|
3,341
|
|
|
3,341
|
Common shares issuable for 2017 Subordinated Note Financing interest expense |
|
|
500
|
|
|
|
|
500
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
$ 1
|
(490)
|
|
489
|
|
|
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
317,804
|
|
|
|
|
|
|
Common shares issued for Opus interest expense (in shares) |
|
91,767
|
|
|
|
|
|
|
Common shares issuable for Opus interest expense |
|
|
|
|
165
|
|
|
165
|
Common shares issued for Opus debt |
|
|
|
|
500
|
|
|
500
|
Common shares issued for Opus debt (in shares) |
|
396,825
|
|
|
|
|
|
|
Non-controlling interest in subsidiaries |
|
|
|
|
(3,467)
|
|
3,467
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
|
(12,208)
|
(12,208)
|
Net loss attributable to common stockholders |
|
|
|
|
|
(12,762)
|
|
(12,762)
|
Issuance of preferred A for at-the-market offering, net |
|
|
|
|
523
|
|
|
523
|
Issuance of preferred A for at-the-market offering, net (in shares) |
26,111
|
|
|
|
|
|
|
|
Write off of Partner company note receivable |
|
|
|
|
(2)
|
|
|
(2)
|
Balance at Sep. 30, 2019 |
$ 1
|
$ 70
|
500
|
|
445,966
|
(420,742)
|
49,205
|
75,000
|
Balance (in shares) at Sep. 30, 2019 |
1,026,111
|
70,335,534
|
|
|
|
|
|
|
Balance at Dec. 31, 2019 |
$ 1
|
$ 74
|
500
|
|
461,874
|
(436,234)
|
46,317
|
72,532
|
Balance (in shares) at Dec. 31, 2019 |
1,341,167
|
74,027,425
|
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
|
10,319
|
|
|
10,319
|
Issuance of common stock related to equity plans |
|
$ 2
|
|
|
(2)
|
|
|
|
Issuance of common stock related to equity plans (in shares) |
|
2,307,231
|
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
|
90
|
|
|
90
|
Issuance of common stock under ESPP (in shares) |
|
53,268
|
|
|
|
|
|
|
Issuance of common stock for at-the-market offering, net |
|
$ 17
|
|
|
43,183
|
|
|
43,200
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
16,378,234
|
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
|
(4,507)
|
|
|
(4,507)
|
Repurchase of Series A preferred stock, net |
|
|
|
$ (70)
|
(2)
|
|
|
(72)
|
Repurchase of Series A preferred stock (in shares) |
(5,000)
|
|
|
|
|
|
|
|
Retirement of Series A preferred stock |
|
|
|
$ 70
|
|
|
|
|
Retirement of Series A preferred stock |
|
|
|
|
(70)
|
|
|
|
Issuance of Series A preferred stock for cash, net |
$ 2
|
|
|
|
35,466
|
|
|
35,468
|
Issuance of Series A preferred stock for cash, net (in shares) |
2,090,971
|
|
|
|
|
|
|
|
Partner company's offering, net |
|
|
|
|
53,698
|
|
|
53,698
|
Partner company's at-the-market offering, net |
|
|
|
|
33,500
|
|
|
33,500
|
Partner company's preferred stock offering, net |
|
|
|
|
7,088
|
|
|
7,088
|
Partner company's dividends declared and paid |
|
|
|
|
50
|
|
|
50
|
Reclass partner company's warrants from liability to equity |
|
|
|
|
1,216
|
|
|
1,216
|
Issuance of partner company's common shares for research and development expenses |
|
|
|
|
42
|
|
|
42
|
Partner company's exercise of warrants for cash |
|
|
|
|
13
|
|
|
13
|
Partner company's ESPP |
|
|
|
|
349
|
|
|
349
|
Issuance of partner company warrants in conjunction with Horizon Notes |
|
|
|
|
|
|
|
0
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
$ 1
|
(500)
|
|
1,816
|
|
|
1,317
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
982,216
|
|
|
|
|
|
|
Common shares issuable for service |
|
|
18
|
|
|
|
|
18
|
Issuance of warrants in conjunction with Oaktree Note |
|
|
|
|
4,419
|
|
|
4,419
|
Non-controlling interest in subsidiaries |
|
|
|
|
(73,981)
|
|
73,981
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
|
(41,264)
|
(41,264)
|
Net loss attributable to common stockholders |
|
|
|
|
|
(41,231)
|
|
(41,231)
|
Balance at Sep. 30, 2020 |
$ 3
|
$ 94
|
18
|
|
574,461
|
(477,465)
|
79,034
|
176,145
|
Balance (in shares) at Sep. 30, 2020 |
3,427,138
|
93,748,374
|
|
|
|
|
|
|
Balance at Jun. 30, 2020 |
$ 3
|
$ 86
|
813
|
|
521,493
|
(461,918)
|
56,381
|
116,858
|
Balance (in shares) at Jun. 30, 2020 |
2,693,806
|
86,113,331
|
|
|
|
|
|
|
Stock-based compensation expense |
|
|
|
|
3,171
|
|
|
3,171
|
Issuance of common stock related to equity plans (in shares) |
|
268,800
|
|
|
|
|
|
|
Issuance of common stock under ESPP |
|
|
|
|
180
|
|
|
180
|
Issuance of common stock for at-the-market offering, net |
|
$ 7
|
|
|
21,110
|
|
|
21,117
|
Issuance of common stock for at-the-market offering, net (in shares) |
|
7,064,214
|
|
|
|
|
|
|
Preferred A dividends declared and paid |
|
|
|
|
(1,719)
|
|
|
(1,719)
|
Issuance of Series A preferred stock for cash, net |
|
|
|
|
11,965
|
|
|
11,965
|
Issuance of Series A preferred stock for cash, net (in shares) |
733,332
|
|
|
|
|
|
|
|
Partner company's offering, net |
|
|
|
|
18,774
|
|
|
18,774
|
Partner company's at-the-market offering, net |
|
|
|
|
23,053
|
|
|
23,053
|
Partner company's preferred stock offering, net |
|
|
|
|
7,088
|
|
|
7,088
|
Partner company's dividends declared and paid |
|
|
|
|
50
|
|
|
50
|
Reclass partner company's warrants from liability to equity |
|
|
|
|
1,216
|
|
|
1,216
|
Issuance of partner company's common shares for research and development expenses |
|
|
|
|
21
|
|
|
21
|
Common shares issued for 2017 Subordinated Note Financing interest expense |
|
$ 1
|
(500)
|
|
810
|
|
|
311
|
Common shares issued for 2017 Subordinated Note Financing interest expense (in shares) |
|
302,029
|
|
|
|
|
|
|
Write off common shares issuable for 2019 Notes interest expense |
|
|
(313)
|
|
|
|
|
(313)
|
Common shares issuable for service |
|
|
18
|
|
|
|
|
18
|
Issuance of warrants in conjunction with Oaktree Note |
|
|
|
|
4,419
|
|
|
4,419
|
Non-controlling interest in subsidiaries |
|
|
|
|
(37,070)
|
|
37,070
|
|
Net loss attributable to non-controlling interest |
|
|
|
|
|
|
(14,417)
|
(14,417)
|
Net loss attributable to common stockholders |
|
|
|
|
|
(15,547)
|
|
(15,547)
|
Balance at Sep. 30, 2020 |
$ 3
|
$ 94
|
$ 18
|
|
$ 574,461
|
$ (477,465)
|
$ 79,034
|
$ 176,145
|
Balance (in shares) at Sep. 30, 2020 |
3,427,138
|
93,748,374
|
|
|
|
|
|
|